Physical activity modifies the associations between genetic variants and blood pressure in European adolescents.

doi:10.1016/j.jpeds.2014.07.007

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Article

Physical activity modifies the associations between genetic variants and blood pressure in European adolescents.

The Journal of pediatrics - 1 Nov 2014

de Moraes Augusto César Ferreira, Fernández-Alvira Juan Miguel, Carvalho Heráclito Barbosa, Meirhaeghe Aline, Dallongeville Jean, Kafatos Anthony, Marcos Ascensión, Molnar Dénes, Manios Yannis, Ruiz Jonatan R, Labayen Idoia, Widhalm Kurt, Breidenassel Christina, Gonzalez-Gróss Marcela, Moreno Luis A

Abstract excerpt

We hypothesized that physical activity and sedentary behavior could modify the associations between known genetic variants blood pressure-associated genes in European adolescents. Meeting current physical activity recommendations (≥ 60 minutes/day) was able attenuate the deleterious effect of the NOS3 rs3918227 polymorphism on systolic blood pressure in European adolescents.

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PMID: 25129643
DOI: 10.1016/j.jpeds.2014.07.007

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NOS3

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