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Article

Response of human DNA polymerase iota to DNA lesions

15 Feb 2001

Abstract excerpt

Lesion bypass is an important mechanism to overcome replication blockage by DNA damage. Translesion synthesis requires a DNA polymerase (Pol). Human Pol iota encoded by the RAD30B gene is a recently identified DNA polymerase that shares sequence similarity to Pol eta. To investigate whether human Pol iota plays a role in lesion bypass we examined the response of this polymerase to several types of DNA damage in...

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PMID: 11160925
DOI: 10.1093/nar/29.4.928

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