Article
Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development.
Cancer research - 15 Sept 2005
Wijnhoven Susan W P, Zwart Edwin, Speksnijder Ewoud N, Beems Rudolf B, Olive Kenneth P, Tuveson David A, Jonkers Jos, Schaap Mirjam M, van den Berg Jolanda, Jacks Tyler, van Steeg Harry, de Vries Annemieke
Abstract excerpt
The tumor suppressor gene p53 has an apparent role in breast tumor development in humans, as approximately 30% of sporadic tumors acquire p53 mutations and Li-Fraumeni syndrome patients carrying germ line p53 mutations frequently develop breast tumors at early age. In the present study, conditional expression of a targeted mutation is used to analyze the role of the human R273H tumor-associated hotspot mutation...
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