Article
A mutant HBs antigen (HBsAg)183-191 epitope elicits specific cytotoxic T lymphocytes in acute hepatitis B patients.
Clinical and experimental immunology - 1 Mar 2008
Liu H-G, Fan Z-P, Chen W-W, Yang H-Y, Liu Q-F, Zhang H, Tien P, Wang F-S
Abstract excerpt
HBs antigen (HBsAg)183-191 (FLLTRILTI, R187 peptide) is a dominant human leucocyte antigen-A2 (HLA-A2)-restricted epitope associated with hepatitis B virus (HBV) infection in Caucasian populations. However, its prevalence is poorly understood in China, where there is a high incidence of HBV infection. In this report, we sequenced the region of HBsAg derived from 103 Chinese patients. Approximately 16.5% of the...
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