Article
The high prevalence of the I27 mutant HBcAg18-27 epitope in Chinese HBV-infected patients and its cross-reactivity with the V27 prototype epitope.
Clinical immunology (Orlando, Fla.) - 1 Dec 2007
Liu Heng-Gui, Chen Wei-wei, Fan Zhen-Ping, Yang Hui-ying, Shi Ming, Zhang Zheng, Luan Shen-Shun, Zhang Hui, Lu Peng, Tien Po, Wang Fu-Sheng
Abstract excerpt
HBcAg18-27 (FLPSDFFPSV, V27 epitope) is a dominant HLA-A2-restricted epitope in hepatitis B virus (HBV)-infected patients. So far, the occurrence of the epitope has not been assessed in China, where the prevalence of chronic HBV infection is high. In this report, we sequenced the HBV core gene in 105 Chinese patients with chronic HBV infection. Approximately 93.3% (98/105) of the core genes that were sequenced...
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