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RAPGEF1 gene variants associated with type 2 diabetes in the Korean population.

Diabetes research and clinical practice - 1 May 2009

Hong Kyung-Won, Jin Hyun-Seok, Lim Ji-Eun, Ryu Ha-Jung, Go Min Jin, Lee Jong-Young, Woo Jeong-Taek, Park Hun Kuk, Oh Bermseok

Abstract excerpt

Under the activation of insulin receptors, glucose transporter 4 (Glut4) translocation is regulated by two signal transduction pathways. These pathways are the PI 3-kinase-dependent pathway and the CAP/TC10 pathway. The adaptor protein Rap guanine exchange factor 1 (RAPGEF1) also known as C3G is a component of the CAP/TC10 pathway. Defects in the RAPGEF1 protein may contribute to insulin resistance and type 2...

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Identifiers

PMID: 19297053
DOI: 10.1016/j.diabres.2009.02.019

Genes

RAPGEF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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