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Article

A SAP30 complex inhibits IFN-beta expression in Rift Valley fever virus infected cells.

PLoS pathogens - 1 Jan 2008

Le May Nicolas, Mansuroglu Zeyni, Léger Psylvia, Josse Thibaut, Blot Guillaume, Billecocq Agnès, Flick Ramon, Jacob Yves, Bonnefoy Eliette, Bouloy Michèle

Abstract excerpt

Rift Valley fever virus (RVFV) nonstructural protein NSs acts as the major determinant of virulence by antagonizing interferon beta (IFN-beta) gene expression. We demonstrate here that NSs interacts with the host protein SAP30, which belongs to Sin3A/NCoR/HDACs repressor complexes and interacts with the transcription factor YY1 that regulates IFN-beta gene expression. Using confocal microscopy and chromatin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18225953
DOI: 10.1371/journal.ppat.0040013
PMCID: PMC2323286

Genes

SAP30

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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