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Article

Rift Valley fever virus NSs inhibits host transcription independently of the degradation of dsRNA-dependent protein kinase PKR.

Virology - 20 Jan 2013

Kalveram Birte, Lihoradova Olga, Indran Sabarish V, Lokugamage Nandadeva, Head Jennifer A, Ikegami Tetsuro

Abstract excerpt

Rift Valley fever virus (RVFV) encodes one major virulence factor, the NSs protein. NSs suppresses host general transcription, including interferon (IFN)-β mRNA synthesis, and promotes degradation of the dsRNA-dependent protein kinase (PKR). We generated a novel RVFV mutant (rMP12-NSsR173A) specifically lacking the function to promote PKR degradation. rMP12-NSsR173A infection induces early phosphorylation of...

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Identifiers

PMID: 23063407
DOI: 10.1016/j.virol.2012.09.031
PMCID: PMC3534933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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