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Article

Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins

2 Jul 2016

Abstract excerpt

Rift Valley fever is a mosquito-borne zoonotic disease that affects both ruminants and humans. The nonstructural (NS) protein, which is a major virulence factor for Rift Valley fever virus (RVFV), is encoded on the S-segment. Through the cullin 1-Skp1-Fbox E3 ligase complex, the NSs protein promotes the degradation of at least two host proteins, the TFIIH p62 and the PKR proteins. NSs protein bridges the Fbox...

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PMID: 27368371
DOI: 10.1186/s12985-016-0573-8

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