Article
The pigtail macaque MHC class I allele Mane-A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion.
Journal of medical primatology - 1 Oct 2005
Smith Miranda Z, Fernandez Caroline S, Chung Amy, Dale C Jane, De Rose Robert, Lin Jie, Brooks Andrew G, Krebs Kendall C, Watkins David I, O'Connor David H, Davenport Miles P, Kent Stephen J
Abstract excerpt
The pigtail macaque (Macaca nemestrina) is a common model for the study of AIDS. The pigtail major histocompatibility complex class I allele Mane-A*10 restricts an immunodominant simian immunodeficiency virus (SIV) Gag epitope (KP9) which rapidly mutates to escape T cell recognition following acute simian/human immunodeficiency virus infection. Two technologies for the detection of Mane-A*10 in outbred pigtail...
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