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Article

Development and Validation of a Novel and Rapid Molecular Detection Method for High-Risk Human Papillomavirus in Formalin-Fixed, Paraffin-Embedded Tumor Tissue.

The Journal of molecular diagnostics : JMD - 1 Feb 2020

Mes Steven W, Heideman Daniëlle A M, Bloemena Elisabeth, Brink Arjen, Bogaarts Martijn, Leemans C René, Brakenhoff Ruud H

Abstract excerpt

The most widely applied algorithm for human papillomavirus (HPV) detection in formalin-fixed, paraffin-embedded (FFPE) specimens of oropharyngeal head and neck squamous cell carcinoma (HNSCC) consists of p16INK4A immunostaining followed by PCR-based detection of high-risk HPV DNA on p16INK4A-immunopositive samples. However, in nonoropharyngeal HNSCC this algorithm fails, hampering correct interpretation of the...

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Identifiers

PMID: 31837430
DOI: 10.1016/j.jmoldx.2019.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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