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Article

Characterization and importance of the dimer interface of human calcium-activated nucleotidase.

Biochemistry - 15 Jan 2008

Yang Mingyan, Horii Katsunori, Herr Andrew B, Kirley Terence L

Abstract excerpt

Human calcium-activated nucleotidase (CAN) exists as both a membrane-bound form in the endoplasmic reticulum and pre-Golgi intermediate membranes and as a secreted, soluble form. Although the wild-type human enzyme hydrolyzes ADP poorly, engineered soluble human proteins (SCANs) hydrolyze ADP much more efficiently, making them potentially useful therapeutic proteins for treatment of human clotting pathologies....

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Identifiers

PMID: 18067325
DOI: 10.1021/bi701578m
PMCID: PMC2538946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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