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Article

Mutual exclusiveness between PIK3CA and KRAS mutations in endometrial carcinoma.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jan 2000

Kang S, Seo S S, Chang H J, Yoo C W, Park S Y, Dong S M

Abstract excerpt

In endometrial carcinomas (ECs), previous report suggested that PIK3CA mutations do not coexist with KRAS mutations, but the significant mutual exclusiveness has not been demonstrated. In this study, we examined the mutation frequency of PIK3CA in EC and its mutual exclusiveness with KRAS mutation. We performed mutational analysis of PIK3CA through a polymerase chain reaction single-strand conformation...

Read the complete abstract on PubMed

Topics

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Share to Class I Phosphatidylinositol 3-Kinases
Share to Endometrial Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-akt

Share to Proto-Oncogene Proteins p21(ras)

Share to ras Proteins

Source

Identifiers

PMID: 18221484
DOI: 10.1111/j.1525-1438.2007.01172.x

Genes

KRAS
PTEN
ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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