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Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present

10 Jun 2022

Abstract excerpt

Ribonucleotide reductase (RR) is an essential multi-subunit enzyme found in all living organisms; it catalyzes the rate-limiting step in dNTP synthesis, namely, the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. As expression levels of human RR (hRR) are high during cell replication, hRR has long been considered an attractive drug target for a range of proliferative diseases,...

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PMID: 35740940
DOI: 10.3390/biom12060815

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