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Article

The Enzyme Ribonucleotide Reductase: Target for Antitumor and Anti-HIV Therapy

1 Jan 1997

Abstract excerpt

Ribonucleotide reductase is the rate-limiting enzyme of DNA synthesis, and it has been shown to be linked with malignant transformation and tumor cell proliferation. It was therefore considered as an excellent target for cancer chemotherapy. This article reviews the in vitro and in vivo effects of hydroxyurea the first inhibitor of the enzyme, which is currently used in general clinical practice. In addition, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9439883
DOI: 10.3109/10408369709006424

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