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Article

Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein.

Biochemical pharmacology - 1 Mar 2016

Liu Xia, Xu Zhijian, Hou Chuanwei, Wang Meng, Chen Xinhuan, Lin Qinghui, Song Rui, Lou Meng, Zhu Lijun, Qiu Yunqing, Chen Zhi, Yang Chunhao, Zhu Weiliang, Shao Jimin

Abstract excerpt

Chronic hepatitis B virus (HBV) infection is a key factor for hepatocellular carcinoma worldwide. Ribonucleotide reductase (RR) regulates the deoxyribonucleoside triphosphates biosynthesis and serves as a target for anti-cancer therapy. Here, we demonstrate that RR is essential for HBV replication and the viral covalently-closed-circular DNA (cccDNA) synthesis in host liver cells. By performing computer-assisted...

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Share to DNA, Circular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26774458
DOI: 10.1016/j.bcp.2016.01.003

Genes

RRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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