Article
Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3.
Nature chemical biology - 1 Oct 2018
Fu Yuan, Long Marcus J C, Wisitpitthaya Somsinee, Inayat Huma, Pierpont Timothy M, Elsaid Islam M, Bloom Jordana C, Ortega Joaquin, Weiss Robert S, Aye Yimon
Abstract excerpt
Since the origins of DNA-based life, the enzyme ribonucleotide reductase (RNR) has spurred proliferation because of its rate-limiting role in de novo deoxynucleoside-triphosphate (dNTP) biosynthesis. Paradoxically, the large subunit, RNR-α, of this obligatory two-component complex in mammals plays a context-specific antiproliferative role. There is little explanation for this dichotomy. Here, we show that RNR-α...
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