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Article

Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics.

European journal of clinical pharmacology - 1 Jun 2006

Al Koudsi Nael, Mwenifumbo Jill C, Sellers Edward M, Benowitz Neal L, Swan Gary E, Tyndale Rachel F

Abstract excerpt

OBJECTIVE: The impact of CYP2A6*21 (K476R) on in vivo nicotine metabolism and disposition was investigated. METHODS: A two-step allele-specific PCR assay was developed to detect the 6573A>G single nucleotide polymorphism (SNP) in CYP2A6*21. Nicotine metabolism phenotypes from a previously described intravenous labeled nicotine and cotinine infusion study [1] was used to assess the impact of CYP2A6*21. Genomic DNA...

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Source

Identifiers

PMID: 16758265
DOI: 10.1007/s00228-006-0113-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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