Article
The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning.
The Biochemical journal - 1 Apr 2008
Golubovskaya Vita M, Finch Richard, Zheng Min, Kurenova Elena V, Cance William G
Abstract excerpt
It is known that p53 alterations are commonly found in tumour cells. Another marker of tumorigenesis is FAK (focal adhesion kinase), a non-receptor kinase that is overexpressed in many types of tumours. Previously we determined that the N-terminal domain of FAK physically interacted with the N-te...
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