Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53-Dependent repression of focal adhesion kinase in response to estradiol in breast cancer cell-lines.

Cancer letters - 28 Jan 2011

Anaganti Suresh, Fernández-Cuesta Lynnette, Langerød Anita, Hainaut Pierre, Olivier Magali

Abstract excerpt

Mutations in the TP53 suppressor gene are frequent in breast cancers. These mutations are associated with poor prognosis, thought to be due to proliferative advantage and poor response to chemotherapy associated with loss of p53 function. The focal adhesion kinase (FAK/PTK2), a tyrosine kinase, is over-expressed in a variety of human tumors including breast cancers. FAK is a critical regulator of adhesion and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Estradiol
Share to Focal Adhesion Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Oligonucleotide Array Sequence Analysis

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Small Interfering

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 21071137
DOI: 10.1016/j.canlet.2010.10.008

Genes

PTK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53-Dependent repression of focal adhesion kinase in response to estradiol in breast cancer cell-lines.PMID 21071137Read ↗

Focal adhesion kinase and p53 signal transduction pathways in cancer.Semantic proximity Read ↗

p53 regulates FAK expression in human tumor cells.Semantic proximity Read ↗

FAK overexpression and p53 mutations are highly correlated in human breast cancer.Semantic proximity Read ↗

Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular CarcinomaSemantic proximity Read ↗

OMICs based identification of the mechanisms that underpin FAK's regulation of gene expressionSemantic proximity Read ↗

Focal adhesion kinase and cancer.Semantic proximity Read ↗

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development and TherapySemantic proximity Read ↗

FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent mannerSemantic proximity Read ↗

Clinical significance of FAK expression in human neoplasia.Semantic proximity Read ↗

FAK regulates biological processes important for the pathogenesis of cancer.Semantic proximity Read ↗

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer DevelopmentSemantic proximity Read ↗

Understanding the Roles of FAK in CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.