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Article

p53 regulates FAK expression in human tumor cells.

Molecular carcinogenesis - 1 May 2008

Golubovskaya Vita M, Finch Richard, Kweh Frederick, Massoll Nicole A, Campbell-Thompson Martha, Wallace Margaret R, Cance William G

Abstract excerpt

Attenuation of the p53 protein is one of the most common abnormalities in human tumors. Another important marker of tumorigenesis is focal adhesion kinase (FAK), a 125-kDa tyrosine kinase that is overexpressed at the mRNA and protein levels in a variety of human tumors. FAK is a critical regulator of adhesion, motility, metastasis, and survival signaling. We have characterized the FAK promoter and demonstrated...

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Identifiers

PMID: 17999388
DOI: 10.1002/mc.20395
PMCID: PMC4562219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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