Article
An N-terminal region of mot-2 binds to p53 in vitro.
Neoplasia (New York, N.Y.) - 1 Jan 2000
Kaul S C, Reddel R R, Mitsui Y, Wadhwa R
Abstract excerpt
The mouse mot-2 protein was earlier shown to bind to the tumor suppressor protein, p53. The mot-2 binding site of p53 was mapped to C-terminal amino acid residues 312-352, which includes the cytoplasmic sequestration domain. In the present study, we have found that both mot-1 and mot-2 bind to p53 in vitro. By using His-tagged deletion mutant proteins, the p53-binding domain of mot-2 was mapped to its N-terminal...
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