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Article

Regions within the N-terminal domain of human topoisomerase I exert important functions during strand rotation and DNA binding.

Journal of molecular biology - 6 Feb 2004

Frøhlich Rikke From, Andersen Félicie Faucon, Westergaard Ole, Andersen Anni Hangaard, Knudsen Birgitta Ruth

Abstract excerpt

The human topoisomerase I N-terminal domain is the only part of the enzyme still not crystallized and the function of this domain remains enigmatical. In the present study, we have addressed the specific functions of individual N-terminal regions of topoisomerase I by characterizing mutants lacking amino acid residues 1-202 or 191-206 or having tryptophane-205 substituted by glycine in a broad variety of in vitro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14741206
DOI: 10.1016/j.jmb.2003.12.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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