Article
The (-590 C/T) polymorphism in the interleukin-4 gene is associated with increased risk for early stages of corolectal adenocarcinoma.
In vivo (Athens, Greece) - 1 Jan 2000
Yannopoulos Athanasios, Nikiteas Nikolaos, Chatzitheofylaktou Agapi, Tsigris Christos
Abstract excerpt
BACKGROUND: In the light of the known association between several carcinomas and the -590C/T polymorphism, which affects transcription of the antitumor interleukin-4 (IL-4) gene, the purpose of this study was to investigate the possible contribution of this polymorphism to the development of colorectal cancer. MATERIALS AND METHODS: The -590C/T polymorphism was examined in DNA samples of 93 patients with...
Topics
- Adenocarcinoma
- Alleles
- Colorectal Neoplasms
- Gene Frequency
- Humans
- Interleukin-4
- Polymorphism, Genetic
- Risk Factors