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Article

Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in Staphylococcus epidermidis.

Nucleic acids research - 1 Mar 2008

Jeng Wen-Yih, Ko Tzu-Ping, Liu Chia-I, Guo Rey-Ting, Liu Chien-Liang, Shr Hui-Lin, Wang Andrew H-J

Abstract excerpt

Expression of the gene cluster icaADBC is necessary for biofilm production in Staphylococcus epidermidis. The ica operon is negatively controlled by the repressor IcaR. Here, the crystal structure of IcaR was determined and the refined structure revealed a homodimer comprising entirely alpha-helices, typical of the tetracycline repressor protein family for gene regulations. The N-terminal domain contains a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

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Share to Protein Structure, Tertiary

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Identifiers

PMID: 18208836
DOI: 10.1093/nar/gkm1176
PMCID: PMC2275139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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