<i>icaR</i> Encodes a Transcriptional Repressor Involved in Environmental Regulation of <i>ica</i> Operon Expression and Biofilm Formation in <i>Staphylococcus epidermidis</i>

Abstract excerpt

Biofilm formation in Staphylococcus epidermidis is dependent upon the ica operon-encoded polysaccharide intercellular adhesin, which is subject to phase-variable and environmental regulation. The icaR gene, located adjacent to the ica operon, appears to be a member of the tetR family of transcriptional regulators. In the reference strain RP62A, reversible inactivation of the ica operon by IS256 accounts for 25 to...

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