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Article

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology.

Journal of cellular and molecular medicine - 1 Jan 2000

Liu R, Zhou X-W, Tanila H, Bjorkdahl C, Wang J-Z, Guan Z-Z, Cao Y, Gustafsson J-A, Winblad B, Pei J-J

Abstract excerpt

Down-regulation of protein phosphatase 2A (PP2A) is thought to play a critical role in tau hyperphosphorylation in Alzheimer's disease (AD). In vitro phosphorylation of PP2A catalytic subunit at Y307 efficiently inactivates PP2A. A specific antibody against phosphorylated (p) PP2A (Y307) (PP2Ac-Yp307) was used to investigate possible PP2A down-regulation by known pathophysiological changes associated with AD,...

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Identifiers

PMID: 18208556
DOI: 10.1111/j.1582-4934.2008.00249.x
PMCID: PMC3823485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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