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Article

Expression of protein phosphatase 2A mutants and silencing of the regulatory B alpha subunit induce a selective loss of acetylated and detyrosinated microtubules.

Journal of neurochemistry - 1 May 2007

Nunbhakdi-Craig Viyada, Schuechner Stefan, Sontag Jean-Marie, Montgomery Lisa, Pallas David C, Juno Claudia, Mudrak Ingrid, Ogris Egon, Sontag Estelle

Abstract excerpt

Carboxymethylation and phosphorylation of protein phosphatase 2A (PP2A) catalytic C subunit are evolutionary conserved mechanisms that critically control PP2A holoenzyme assembly and substrate specificity. Down-regulation of PP2A methylation and PP2A enzymes containing the B alpha regulatory subu...

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Identifiers

PMID: 17394530
DOI: 10.1111/j.1471-4159.2007.04503.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17394530-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Expression of protein phosphatase 2A mutants and silencing of the regulatory B alpha subunit induce a selective loss of acetylated and detyrosinated microtubules.PMID 17394530Read ↗

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Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B).Semantic proximity Read ↗

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