Article

Cellular and molecular mechanisms by which specific GSK3 inhibition affects the processing of the Amyloid Precursor Protein

2012-01-01

Abstract excerpt

Alzheimer’s disease (AD) has long been associated with altered activity of the serine/threonine kinases, Glycogen Synthase Kinase-3 (GSK3) isozymes, which are proposed to contribute to both neurofibrillary tangles and amyloid plaque formation. While the molecular links between GS3K and tau pathology are well established, the molecular basis by which GSK3 affects the formation of amyloid-β (Aβ) remains unknown. The...

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Literature Corpus work: 2202e1b8-e92f-508d-86d3-5d60085efe90
DOI: 10.25560/9991

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