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Overexpression of βTrCP1 elicits cell death in cisplatin-induced senescent cells

25 Mar 2025

Abstract excerpt

Senescence is a non-proliferative cellular state derived from aging or in response to exogenous insults, such as those that cause DNA damage. As a result of cancer treatments like cisplatin, certain tumor cells may undergo senescence. However, rather than being beneficial for patients, this is detrimental because these cells might proliferate again under specific conditions and, more importantly, because they...

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PMID: 40133262
DOI: 10.1038/s41419-025-07556-6

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