Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autophagic activity dictates the cellular response to oncogenic RAS

30 Jul 2012

Abstract excerpt

RAS is frequently mutated in human cancers and has opposing effects on autophagy and tumorigenesis. Identifying determinants of the cellular responses to RAS is therefore vital in cancer research. Here, we show that autophagic activity dictates the cellular response to oncogenic RAS. N-terminal Apoptosis-stimulating of p53 protein 2 (ASPP2) mediates RAS-induced senescence and inhibits autophagy. Oncogenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer-related Molecular Pathways
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22847423
DOI: 10.1073/pnas.1120193109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autophagic activity dictates the cellular response to oncogenic RASPMID 22847423Read ↗

Autophagy in Ras-Induced Malignant Transformation: Fatal or Vital?Semantic proximity Read ↗

Ras and autophagy in cancer development and therapySemantic proximity Read ↗

p53-mediated autophagic regulation: A prospective strategy for cancer therapySemantic proximity Read ↗

Autophagy Suppresses Tumorigenesis through Elimination of p62Semantic proximity Read ↗

Autophagy Suppresses Tumorigenesis through Elimination of p62Semantic proximity Read ↗

Regulation of autophagy and EMT by the interplay between p53 and RAS during cancer progression (Review)Semantic proximity Read ↗

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen speciesSemantic proximity Read ↗

Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.Semantic proximity Read ↗

Oncogenic RAS induces a distinctive form of non-canonical autophagy mediated by the P38-ULK1-PI4KB axisSemantic proximity Read ↗

Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic SurvivalSemantic proximity Read ↗

Defective autophagy control by the p53 rheostat in cancerSemantic proximity Read ↗

ATG5 can regulate p53 expression and activationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.