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Article

Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.

Molecular and cellular biology - 1 Jan 2007

Kim Jung-Sik, Lee Carolyn, Bonifant Challice L, Ressom Habtom, Waldman Todd

Abstract excerpt

In an effort to identify genes whose expression is regulated by activated phosphatidylinositol 3-kinase (PI3K) signaling, we performed microarray analysis and subsequent quantitative reverse transcription-PCR on an isogenic set of PTEN gene-targeted human cancer cells. Numerous p53 effectors were upregulated following PTEN deletion, including p21, GDF15, PIG3, NOXA, and PLK2. Stable depletion of p53 led to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17060456
DOI: 10.1128/MCB.00537-06
PMCID: PMC1800819

Genes

PTEN
GDF15
PLK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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