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Article

Alterations in intranuclear localization of Runx2 affect biological activity.

Journal of cellular physiology - 1 Dec 2006

Zaidi Sayyed K, Javed Amjad, Pratap Jitesh, Schroeder Tania M, J Westendorf Jennifer, Lian Jane B, van Wijnen Andre J, Stein Gary S, Stein Janet L

Abstract excerpt

The transcription factor Runx2 controls osteoblast proliferation and differentiation. Runx2 organizes and assembles gene-regulatory complexes in nuclear microenvironments where target genes are activated or suppressed in a context-dependent manner. Intranuclear localization of Runx2 is mediated by the nuclear matrix-targeting signal (NMTS), an autonomous motif with a loop (L1)-turn-loop (L2) structure that forms...

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Identifiers

PMID: 16972259
DOI: 10.1002/jcp.20791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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