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Reconstitution of Runx2/Cbfa1‐null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation

22 Aug 2006

Abstract excerpt

The Runx2/Cbfa1 transcription factor is a scaffolding protein that promotes osteoblast differentiation; however, the specific Runx2-functional domains required for induction of the osteogenic lineage remain to be identified. We approached this question using a TERT-immortalized cell line derived from calvaria of Runx2-null mice by reconstituting the osteogenic activity with wild-type and deletion mutants of...

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PMID: 16927309
DOI: 10.1002/jcb.21039

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