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Article

Runx2/Cbfa1: A Multifunctional Regulator of Bone Formation

1 Dec 2003

Abstract excerpt

Runx2/Cbfa/AML3 is a member of the runt homology domain family of transcription factors, essential for osteoblast differentiation and bone formation. Defining the molecular mechanisms by which Runx2 can function as a master regulatory gene for activating the program of osteoblastogenesis has provided novel insights for transcriptional regulation of tissue-specific genes. Regulation of Runx expression has the...

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PMID: 14529540
DOI: 10.2174/1381612033453659

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