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Article

Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency.

Journal of molecular biology - 22 May 2016

Mailliot Justine, Garreau de Loubresse Nicolas, Yusupova Gulnara, Meskauskas Arturas, Dinman Jonathan D, Yusupov Marat

Abstract excerpt

The ribosome has been described as a ribozyme in which ribosomal RNA is responsible for peptidyl-transferase reaction catalysis. The W255C mutation of the universally conserved ribosomal protein uL3 has diverse effects on ribosome function (e.g., increased affinities for transfer RNAs, decreased rates of peptidyl-transfer), and cells harboring this mutation are resistant to peptidyl-transferase inhibitors (e.g.,...

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Identifiers

PMID: 26906928
DOI: 10.1016/j.jmb.2016.02.013
PMCID: PMC5331904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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