Article
Genetic polymorphisms of cytochrome P450 among patients with Balkan endemic nephropathy (BEN).
Clinical biochemistry - 1 Mar 2005
Atanasova Srebrena Y, von Ahsen Nicolas, Toncheva Draga I, Dimitrov Tzvetan G, Oellerich Michael, Armstrong Victor W
Abstract excerpt
OBJECTIVES: The concept of multifactorial etiology of BEN anticipates that a combination of polymorphic gene variants and various environmental factors causes an increased risk for the disease. CYP enzymes play a key role in the metabolic activation of environmental chemicals and toxins. CYP3A enzymes are particularly relevant for xenobiotic metabolism because of their broad substrate specificity and abundant...
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