Article
Balkan endemic nephropathy and genetic variants of glutathione S-transferases.
Journal of nephrology - 1 Jan 2000
Andonova Irena E, Sarueva Radoslava B, Horvath Anelia D, Simeonov Valery A, Dimitrov Plamen S, Petropoulos Evangelos A, Ganev Varban S
Abstract excerpt
BACKGROUND: Balkan endemic nephropathy (BEN) is a non-inflammatory, chronic, slow progressing kidney disease, frequently associated with urinary tract tumors. BEN displays familial clustering without an apparent Mendelian inheritance pattern. It has been suggested that environmental toxicants damage urothelial cells in genetically susceptible individuals, which could be the cause of BEN. The metabolism of some...
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