Article
The G2019S LRRK2 mutation in Brazilian patients with Parkinson's disease: phenotype in monozygotic twins.
Movement disorders : official journal of the Movement Disorder Society - 30 Jan 2008
Munhoz Renato P, Wakutani Yosuke, Marras Connie, Teive Helio A, Raskin Salmo, Werneck Lineu C, Moreno Danielle, Sato Christine, Lang Anthony E, Rogaeva Ekaterina
Abstract excerpt
Mutations in the Leucine-Rich Repeat Kinase 2 gene (LRRK2) are mainly responsible for idiopathic Parkinson's disease (PD) with either a dominant pattern of transmission or a sporadic occurrence due to the reduced penetrance. A majority of LRRK2 kindreds demonstrate an extremely variable age-at-onset in affected members of the same family. The G2019S is the most common LRRK2 mutation, which accounts for 1-5% PD...
Topics
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Brazil
- Diseases in Twins
- Female
- Glycine
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation