Article
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.
The EMBO journal - 23 Jan 2008
Twig Gilad, Elorza Alvaro, Molina Anthony J A, Mohamed Hibo, Wikstrom Jakob D, Walzer Gil, Stiles Linsey, Haigh Sarah E, Katz Steve, Las Guy, Alroy Joseph, Wu Min, Py Bénédicte F, Yuan Junying, Deeney Jude T, Corkey Barbara E, Shirihai Orian S
Abstract excerpt
Accumulation of depolarized mitochondria within beta-cells has been associated with oxidative damage and development of diabetes. To determine the source and fate of depolarized mitochondria, individual mitochondria were photolabeled and tracked through fusion and fission. Mitochondria were found...
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