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At the heart of mitochondrial quality control: many roads to the top

5 Feb 2021

Abstract excerpt

Mitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of mitochondrial components across the network by fusion, and segregation of damaged mitochondria by fission prior to mitophagy. In this review, we focus on mitochondrial dynamics (fusion/fission), mitophagy, and other mechanisms supporting mitochondrial quality control...

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Autophagy in Disease and Therapy
Metabolism and Genetic Disorders
Mitochondrial Function and Pathology

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33544154
DOI: 10.1007/s00018-021-03772-3

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