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Article

Stimulation of calcineurin Aalpha activity attenuates muscle pathophysiology in mdx dystrophic mice.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Mar 2008

Stupka Nicole, Schertzer Jonathan D, Bassel-Duby Rhonda, Olson Eric N, Lynch Gordon S

Abstract excerpt

Calcineurin activation ameliorates the dystrophic pathology of hindlimb muscles in mdx mice and decreases their susceptibility to contraction damage. In mdx mice, the diaphragm is more severely affected than hindlimb muscles and more representative of Duchenne muscular dystrophy. The constitutively active calcineurin Aalpha transgene (CnAalpha) was overexpressed in skeletal muscles of mdx (mdx CnAalpha*) mice to...

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Source

Identifiers

PMID: 18199592
DOI: 10.1152/ajpregu.00375.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Stimulation of calcineurin Aalpha activity attenuates muscle pathophysiology in mdx dystrophic mice.PMID 18199592Read ↗

Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx miceSemantic proximity Read ↗

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Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.Semantic proximity Read ↗

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