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Article

Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophin

22 Jan 2014

Abstract excerpt

BACKGROUND: Duchenne muscle dystrophy (DMD) afflicts 1 million boys in the US and has few effective treatments. Constitutive transgenic expression of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α improves skeletal muscle function in the murine "mdx" model of DMD, but how this occurs, or whether it can occur post-natally, is not known. The leading mechanistic...

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PMID: 24447845
DOI: 10.1186/2044-5040-4-2

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Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophinPMID 24447845Read ↗

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