Article
A comparison of the bone and growth phenotype of mdx, mdx:Cmah-/- and mdx:Utrn+/- murine models with the C57BL/10 wild-type mouse.
Disease models & mechanisms - 10 Jan 2020
Wood Claire L, Suchacki Karla J, van 't Hof Rob, Cawthorn Will P, Dillon Scott, Straub Volker, Wong Sze Choong, Ahmed Syed F, Farquharson Colin
Abstract excerpt
The muscular dystrophy X-linked (mdx) mouse is commonly used as a mouse model of Duchenne muscular dystrophy (DMD). Its phenotype is, however, mild, and other mouse models have been explored. The mdx:Cmah-/- mouse carries a human-like mutation in the Cmah gene and has a severe muscle phenotype, but its growth and bone development are unknown. In this study, we compared male mdx, mdx:Utrn+/-, mdx:Cmah-/- and...
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