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Article

SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models.

American journal of physiology. Cell physiology - 1 May 2015

Mázala Davi A G, Pratt Stephen J P, Chen Dapeng, Molkentin Jeffery D, Lovering Richard M, Chin Eva R

Abstract excerpt

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting secondary to repeated muscle damage and inadequate repair. Elevations in intracellular free Ca²⁺ have been implicated in disease progression, and sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase 1 (SERCA1) overexpression has been shown to ameliorate the dystrophic phenotype in mdx mice. The purpose of this study was to assess the...

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Source

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Identifiers

PMID: 25652448
DOI: 10.1152/ajpcell.00341.2014
PMCID: PMC4420794

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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