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Article

Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers.

The Journal of biological chemistry - 30 Nov 2001

Dunn S E, Simard A R, Bassel-Duby R, Williams R S, Michel R N

Abstract excerpt

This study tested the hypothesis that calcineurin signaling is modulated in skeletal muscle cells by fluctuations in nerve-mediated activity. We show that dephosphorylation of NFATc1, MEF2A, and MEF2D transcription factors by calcineurin in all muscle types is dependent on nerve activity and positively correlated with muscle usage under normal weightbearing conditions. With increased nerve-mediated activity,...

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Source

Identifiers

PMID: 11555650
DOI: 10.1074/jbc.M105445200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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