Article
Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.
Molecular and cellular biology - 1 Jun 2003
Parsons Stephanie A, Wilkins Benjamin J, Bueno Orlando F, Molkentin Jeffery D
Abstract excerpt
Calcineurin is a calcium-regulated serine-threonine protein phosphatase that controls developmental and inducible biological responses in diverse cell types, in part through activation of the transcription factor nuclear factor of activated T cells (NFAT). In skeletal muscle, calcineurin has been implicated in the regulation of myoblast differentiation, hypertrophy of mature myofibers, and fiber type switching in...
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