Evaluation of Telomere Length Maintenance Mechanisms in Adrenocortical Carcinoma

Abstract excerpt

CONTEXT: Adrenocortical cancer (ACC) is a rare disease with an often fatal outcome. The clinical and pathological diagnosis of a malignant vs. benign adrenocortical tumor is sometimes challenging. Telomere maintenance mechanisms (TMMs) are critical for the persistence of the malignant phenotype, but little is known about these mechanisms or their diagnostic value in adrenocortical lesions. OBJECTIVE: Tissue...

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