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Article

Multiple mechanisms of telomere maintenance exist in liposarcomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2005

Johnson Jay E, Varkonyi Robert J, Schwalm Jaclyn, Cragle Ryan, Klein-Szanto Andres, Patchefsky Arthur, Cukierman Edna, von Mehren Margaret, Broccoli Dominique

Abstract excerpt

PURPOSE: Telomeres are specialized nucleoprotein complexes that protect and confer stability upon chromosome ends. Loss of telomere function as a consequence of proliferation-associated sequence attrition results in genome instability, which may facilitate carcinogenesis by generating growth-promoting mutations. However, unlimited cellular proliferation requires the maintenance of telomeric DNA; thus, the...

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Identifiers

PMID: 16061847
DOI: 10.1158/1078-0432.CCR-05-0684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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