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Article

Potential clinical treatment prospects behind the molecular mechanism of alternative lengthening of telomeres (ALT)

1 Jan 2023

Abstract excerpt

Normal somatic cells inevitably experience replicative stress and senescence during proliferation. Somatic cell carcinogenesis can be prevented in part by limiting the reproduction of damaged or old cells and removing them from the cell cycle [1, 2]. However, Cancer cells must overcome the issues of replication pressure and senescence as well as preserve telomere length in order to achieve immortality, in...

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PMID: 36860927
DOI: 10.7150/jca.80097

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